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KMID : 1103720130690060449
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Journal of the Korean Society of Radiology
2013 Volume.69 No. 6 p.449 ~ p.455
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Dynamic CT Findings of Pulmonary Hamartoma: A Comparison with Histopathologic Findings
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Cho Wang-Lae
Jeong Yeon-Ju
Lee Chang-Hun
Lee Gee-Won
Kim Kun-Il
Yeom Jeong-A
Kim Yeong-Dae
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Abstract
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Purpose: To describe the dynamic CT findings of pulmonary hamartoma and to compare these findings with histopathologic findings.
Materials and Methods: The Institutional Review Board approved this retrospective study and the requirement for patient informed consent was waived. The hemodynamic CT features of 11 patients (M : F = 6 : 5; mean age, 53.6 years) with pathologically proven pulmonary hamartoma were evaluated. All 11 patients underwent enhanced dynamic CT using a helical technique. A series of images were obtained throughout each nodule with 2.5-mm collimation at 0, 30, 60, 90 and 120 seconds and at 4, 5 and 15 minutes after an intravenous injection of contrast medium. Extents and patterns of enhancement were correlated with histologic tumor components.
Results: All 11 tumors showed persistent enhancement with variable degrees of net enhancement [mean tumor peak enhancement, 48.6 ± 19.0 Hounsfield unit (HU); mean tumor net enhancement, 31.9 ± 11.8 HU] and thick capsular and septal enhancement.
Histologically, all 11 tumors were composed of mature cartilage and loose mesenchymal tissue. A significant positive correlation was found between the net enhancement values and loose connective tissue component percentages (r = 0.749, p = 0.008); further, a negative correlation was found between the net enhancement
values and cartilaginous component percentages (r = -0.813, p = 0.002).
Conclusion: On dynamic CT, hamartoma exhibited persistent enhancement without washout as well as thick capsular and septal enhancements. Net enhancement values were found to be positively correlated with the proportion of the loose connective tissue
component. Thick capsular and septal enhancements were attributed histopathologically to loose connective tissue, separating tumors into cartilaginous lobules.
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KEYWORD
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Lung Neoplasm , Hamartoma , Multidetector Computed Tomography , Pathology
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